Aim There is a growing evidence showing that asymmetric dimethylarginine ( ADMA) and intercellular adhesion molecule-1 ( ICAM-1) are markers of endothelial dysfunction and the degree of coronary collateral circulation in subjects with severe coronary artery stenosis is attributed to endothelial injury. 目的大量研究显示非对称性二甲基精氨酸和细胞间粘附分子是内皮功能不全的标志因子,而内皮损害程度和严重冠状动脉狭窄患者侧支循环形成密切相关。